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Preheat oven to 400 degrees.
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Lightly coat a 16-cup muffin pan with cooking spray.
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Mix together 1 1/2 cups all-purpose flour, sugar, whole-wheat flour, baking powder, baking soda, salt, nutmeg, and cinnamon in a large bowl. Make a well in the center of the mixture.
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Whisk together the buttermilk, applesauce, egg, oil, and vanilla extract in a small bowl.
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Toss the blueberries in 1/4 cup all-purpose flour to lightly coat the berries.
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Pour the buttermilk mixture into the flour mixture and stir until the batter is just moistened. Fold in the blueberries.
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Divide the mixture evenly among the muffin cups. Bake the muffins for 20 minutes. Cool the muffins in the pan on a rack for 5 minutes. Remove the muffins and serve warm or at room temperature.