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Place brisket fat side up into slow cooker, sprinkle garlic powder on top and rub ketchup generously into brisket.
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Add onion slices all around and on top of meat, add enough water to coat the bottom of the cooker.
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Cook on low, all day, for the most tender brisket you will ever eat.
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For gravy, remove brisket and turn thermostat to high.
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Mix flour with 1/4 cup water, add to pot and bring to a boil, stirring constantly.