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Combine the flour, creole seasoning, garlic powder, cayenne, onion powder, and black pepper in a zip lock bag.
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Shake the bag to mix the flour and spices.
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Rinse the shrimp under cold water; place in the bag and shake to coat the shrimp.
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Lay the shrimp in a casserole dish and refrigerate for 30 minutes to rest; do not discard the seasoned flour.
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Combine the minced garlic, butter, hot sauce and cayenne in a saucepan; heat until the butter is melted and keep warm.
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In a deep fryer, heat oil to 375 degrees.
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Remove the shrimp from the refrigerator and re-coat with the remaining seasoned flour.
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Place the shrimp in the hot oil and fry about 2-3 minutes, or until pink; fry in batches if necessary.
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Immediately coat with the spicy buffalo sauce and serve.