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Heat the oven to 325 F and lightly grease and flour a large baking sheet.
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Stir the eggs, instant coffee and vanilla in a small bowl until well blended, set aside.
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Mix the flour, baking powder and salt in a medium bowl, set aside.
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Beat the butter and sugar in a large bowl with an electric mixer set on medium speed until light and fluffy.
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Beat in the egg mixture.
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Gradually add the flour mixture, beating well after each addition.
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Stir in the cranberries.
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Divide the dough into 2 equal portions.
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On a lightly floured surface, shape the dough into 2 logs, each 14 inches long, 1 1/2 inches wide and 1 inch thick.
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Place the logs 2 inches apart on the baking sheet.
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Bake for 25 minutes or until lightly browned.
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Set the baking sheet on a wire rack to cook for 10 minutes.
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Remove the logs and place on a cutting board.
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Using a serrated knife, cut each log diagnolly into 3/4 inch slices.
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Place the slices upright and 1/2 inch apart on the baking sheet.
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Bake for 10 minutes or until slightly dry.
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Remove the biscotti from the baking sheet.
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Cool completely on the wire rack.
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Store in a tightly covered container.