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Mix hamburger, sausage, eggs, and onions well.
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Using a separate bowl, mix the ketchup, barbecue sauce, brown sugar, Worcestershire sauce, and garlic powder with a whisk.
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Combine most (but not all!) of the liquid mixture with the meat mixture and mix well.
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Using a large cutting board or other surface, knead the meat to get as much air out as possible.
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After meat is well kneaded (gently!) place into a greased bread pan.
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Using a rubber spatula, spread the rest of the liquid mixture on top of the meatloaf.
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Bake at 275 degrees Fahrenheit for 2-1/2 hours or until 175 to 180 degrees Fahrenheit internal temperature.