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Preheat oven to 375°; grease a 12-cup muffin pan.
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In a bowl, whisk the flour, baking powder, baking soda, and salt together.
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In another bowl, using an electric mixer on med-high speed, beat sugar and butter until light and fluffy.
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Add eggs, one at a time, beating until fluffy and pale yellow.
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Beat in vanilla until blended.
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With the mixer on low speed, beat in flour mixture alternately with buttermilk, making three additions of flour and two of buttermilk, until just blended.
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Divide batter equally among prepared muffin cups.
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Bake for 25-30 minutes or until tops are golden and a pick comes out clean.
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Let cool in pan on a wire rack for 3 minutes, then transfer to the rack to cool.