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In a bowl, whisk the flour, sugar, baking powder, baking soda, and salt together.
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In another bowl, whisk the buttermilk, egg, and melted butter together; blend well.
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Pour the liquid ingredients over the dry ingredients; mix with a whisk, stopping when everything is just combined (don’t worry if batter is a bit lumpy).
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The batter will bubble and become spongy almost immediately.
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Lightly butter or oil your griddle or skillet; preheat to medium (if using an electric griddle, heat to 350°).
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Spoon ¼ cup batter onto griddle for each pancake, allowing space for spreading.
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When the undersides of the pancakes are golden and the tops are lightly speckled with bubbles that pop and stay open, flip the pancakes over with a wide spatula and cook until the other sides are light brown.
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Serve immediately with topping of choice.