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Preheat oven to 350ºF. Coat a large baking sheet with cooking spray.
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In a medium bowl, combine cream cheese, cheddar cheese and mayonnaise; mix well and set aside.
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Halve jalapenos lengthwise and remove seeds (wear gloves if possible). Stuff jalapeno halves with cream cheese mixture.
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Place egg substitute in a shallow dish. Place Panko bread crumbs in a separate shallow dish.
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Dip stuffed jalapeno halves into egg substitute and then roll in bread crumbs to coat.
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Transfer jalapenos to prepared baking sheet and coat with cooking spray.
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Bake until filling is bubbly, about 30 minutes. Serve hot.